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Title Category Tags Skill Level
Fine-tuning LLMs with PEFT and LoRA Video faster, optimization, performance-tuning, tuning Intermediate, Advanced

Engagements

Re-engineering Lilly’s KisunlaTM into a novel antibody targeting IL13RA2 against GBM using AI-driven macromolecular modeling
Atrium Health Levine Cancer
  • Summary and objectives of the proposed experiments: 
  1. An initial research-based Ab (scFv47, discovered by our collaborator Dr. Balyasnikova) model, modeling Ab-Ag (IL13RA2 against GBM) protein complex, and identifying the binding sites (epitopes) using ROSETTA and AlphaFold2 multimer tools.
  2. Graft the CDRs of scFv (single-chain variable fragment) of antibody or Bispecific T cell engagers (BTEs) onto the template Ab, the framework of Lilly's Kisunla™ Ab drug.
  3. Modify, improve, and optimize the overall or full antibody protein structures using AI-driven macromolecule modeling (AlphaFold3).
  4. Explore single nucleotide polymorphism (SNP), pathogenic genetic variants and N-glycosylation of IL13RA2 (target) protein domain interacting with the Ab candidates among the patient population using ROSETTA software packages.
Status: In Progress

People with Expertise

Anton Semenchenko

Programs

CCMNet

Roles

CCMNet

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Expertise

Ron Rahaman

Georgia Institute of Technology

Programs

Campus Champions

Roles

research software engineer

Ronald Rahaman

Expertise

Jason Wells

Harvard University

Programs

ACCESS CSSN, Campus Champions

Roles

research computing facilitator, cssn

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Expertise

People with Interest

Liwen Shih

University of Houston-Clear Lake

Programs

Campus Champions, ACCESS CSSN

Roles

research computing facilitator, cssn

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Interests

Paul Rulis

University of Missouri-Kansas City

Programs

Campus Champions

Roles

researcher/educator, research computing facilitator

Paul Rulis

Interests

Gregory Bauer

University of Illinois at Urbana-Champaign

Programs

ACCESS CSSN

Roles

research computing facilitator, Affinity Group Leader, Consultant

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Interests