Skip to main content

cpu-architecture

Mentors and Regional Facilitators
Name Region Skills Interests
Adam Carlson Campus Champions
Charles Forsyth Campus Champions
Cody Stevens Campus Champions, CCMNet
Chris Reidy Campus Champions, CCMNet
Daniel Benedict CCMNet
Deborah Penchoff Campus Champions
Elizabeth Leake CCMNet
Jeff Falgout Campus Champions, RMACC
Julie Ma ACCESS CSSN, At-Large, Campus Champions, CAREERS, CCMNet, Northeast
James Hutcheson Campus Champions, ACCESS CSSN
Michael Schnaitter ACCESS CSSN
Ron Rahaman Campus Champions
Ruben Lara Campus Champions
Liwen Shih Campus Champions, ACCESS CSSN, CCMNet
Steven Kuhlo TRECIS
Thomas Pranzatelli
Trey Breckenridge Campus Champions
Projects
There are no projects associated with this topic. Please check back often as more projects are added regularly, or view All Projects.
Blog Entries
There are no Blog Entries associated with this topic.

Affinity Groups

There are no Affinity Groups associated with this topic. View All Affinity Groups.

Announcements

There are no announcements with this tag. View All Announcements.

Upcoming Events & Trainings

No events or trainings are currently scheduled.

Topics from Ask.CI

Loading topics from Ask.CI ...

Engagements

Re-engineering Lilly’s KisunlaTM into a novel antibody targeting IL13RA2 against GBM using AI-driven macromolecular modeling
Atrium Health Levine Cancer
  • Summary and objectives of the proposed experiments: 
  1. An initial research-based Ab (scFv47, discovered by our collaborator Dr. Balyasnikova) model, modeling Ab-Ag (IL13RA2 against GBM) protein complex, and identifying the binding sites (epitopes) using ROSETTA and AlphaFold2 multimer tools.
  2. Graft the CDRs of scFv (single-chain variable fragment) of antibody or Bispecific T cell engagers (BTEs) onto the template Ab, the framework of Lilly's Kisunla™ Ab drug.
  3. Modify, improve, and optimize the overall or full antibody protein structures using AI-driven macromolecule modeling (AlphaFold3).
  4. Explore single nucleotide polymorphism (SNP), pathogenic genetic variants and N-glycosylation of IL13RA2 (target) protein domain interacting with the Ab candidates among the patient population using ROSETTA software packages.
Status: In Progress

People with Expertise

Elizabeth Leake

Texas A&M University

Programs

CCMNet

Roles

mentor, research computing facilitator, CCMNet

Photo of Elizabeth Leake

Expertise

Anton Semenchenko

Programs

CCMNet

Roles

CCMNet

Placeholder headshot

Expertise

Ana Marija Sokovic

University of Illinois at Chicago

Programs

CCMNet

Roles

CCMNet

Placeholder headshot

Expertise

People with Interest

Dr. Nabeel Alzahrani

California State University-San Bernardino

Programs

Campus Champions, CCMNet

Roles

mentor, researcher/educator, research computing facilitator, research software engineer, ci systems engineer, CCMNet

Headshot

Interests

Jeevesh Choudhury

Arizona State University

Programs

CCMNet

Roles

student-facilitator, research software engineer, CCMNet

Placeholder headshot

Interests

Maureen Dougherty

Ecosystem for Research Networking

Programs

OnDemand

Roles

representative, Affinity Group Leader

Placeholder headshot

Interests